Reduced E-cadherin expression contributes to the loss of p27-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas
نویسندگان
چکیده
Maria Letizia Motti, Daniela Califano, Gustavo Baldassarre, Angela Celetti, Francesco Merolla, Floriana Forzati, Maria Napolitano, Barbara Tavernise, Alfredo Fusco and Giuseppe Viglietto Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L.Califano’’ Facolt a di Medicina e Chirurgia, Universit a Federico II, via S. Pansini 5, 80131, Napoli, Italy, Istituto Nazionale Tumori, via M. Semmola, 80131, Napoli, Italy, Divisione di Oncologia Sperimentale 2, CRO National Cancer Institute, Via Pedemontana Occidentale 28, 33081 Aviano, Italy, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L.Califano’’ Facolt a di Medicina e Chirurgia, Universit a Federico II, via S. Pansini 5, 80131, Napoli, Italy and Laboratorio Oncologia Molecolare III, Dipartimento di Medicina Sperimentale e Clinica, Facolt a di Medicina e Chirurgia, Universit a ‘‘Magna Graecia’’, Campus Universitario Germaneto, Viale Europa, 88100 Catanzaro, Italy
منابع مشابه
Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.
In the present study, we have characterized several human thyroid cancer cell lines of different histotypes for their responsiveness to contact inhibition. We found that cells derived from differentiated carcinoma (TPC-1, WRO) arrest in G(1) phase at confluence, whereas cells derived from anaplastic carcinoma (ARO, FRO and FB1) continue to grow after reaching confluence. Furthermore, we provide...
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Loss of E-cadherin (uvomorulin), a Ca2*-dependent cell adhesion mole cule required for normal epithelial function, has been attributed a pathogenetic role in tumor invasion. The expression of E-cadherin was studied in normal and neoplastic follicular epithelium of the human thyroid by Northern blot analysis and immunofluorescence on frozen tissue sections. In the normal thyroid (n = 10) and in ...
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Loss of E-cadherin (uvomorulin), a Ca(2+)-dependent cell adhesion molecule required for normal epithelial function, has been attributed a pathogenetic role in tumor invasion. The expression of E-cadherin was studied in normal and neoplastic follicular epithelium of the human thyroid by Northern blot analysis and immunofluorescence on frozen tissue sections. In the normal thyroid (n = 10) and in...
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